Hypothalamus – connection between the CNS and endocrine system.

Pituitary – is considered the . Two lobes and . Posterior releases and .  Anterior releases which stimulates the adrenal cortexes.  targets the thyroid.  and targets the gonads.  targets all body cells. 

 

Thyroid – and stimulate metabolism.  Also thyroid calcium levels.

Parathyroid – hormone calcium levels.

Thymus – promoted maturation of .

Pancreas – Alpha produce and Beta cells produce .

Adrenals – increase blood glucose levels.  salt and fluid balance along with sodium and potassium balance.

Gonads – produce estrogen, progesterone and testosterone.

                                

The system controls the body through called and consists of glands.  The system exerts its control through nervous impulses.  The system tends to be localized and use ducts.  The word is Greek for “to set into motion” and are needed to maintain body is the sum of cellular process that produce energy needed to grow and repair.

                              

is marked by inadequate insulin activity in the body.  is important to all cells but especially the .  Glucose is the only substance that brain cells can readily and efficiently use as an energy source.  Insulin also allows the body to store energy as , protein, and fat.

The disease is named by a Greek doctor who found that affected peoples urine attracted bees.  Hence translates to “to pass through” and means “honey sweet.”  comes from the Greek work “to change.”  The building process within a cell to build is comes from Greek “Up.”  Breakdown process is called , cata- is Greek for “Down.”  So makes or releases energy and requires energy to drive them.  Insulin stimulates the pathways.  stimulates catabolic action.  When sugar levels are low the body turns to cell break down into free fatty acids.  In the liver catabolism of fatty acids produce .  As this acid accumulates it mixes with acetone and B-hydroxybutric acid and when all 3 are combined makes which is called ketosis. 

Normal blood levels are between 80 to 120 mg/dl.  The cells in the pancreas create and beta cells produce .  Hypoglycemia is often defined as less than 80 mg/dl and hyperglycemia is over 140 mg/dl unless after a meal.  After glucose levels in the blood rise above 180 mg/dl sugar is eliminated in urine.  When glucose spills into urine the is higher in the kidney than blood.  Water follows sugar because of .  The term means glucose in urine.

Type 1 Diabetes also called onset or termed accounts for most diabetic deaths.  It is not uncommon for Type 1 to reach 300 – 500 mg/dl resulting in; (thirst), (excessive urination), and (ravenous appetite). 

Type II Diabetes termed occurs most commonly in patients and as a result decreases the number of insulin receptors per cell.  of all diabetics are .  General treatment is diet and exercise, oral hypoglycemic agents, and finally insulin injections.

Hyperglycemia is termed and hypoglycemia is termed .   is an advanced case of hyperglycemia and is life-threatening.  When the pH level get to 6.9 the patient is hours from death.  The onset is 12 to 24 hours, excessive hunger and thirst with general malaise.  is a major compensatory mechanism to remove CO2.  The breath is fruity or – like smell.  Low levels can be found because of the diuresis leading to cardiac dysrhythmias or death. Management is look for or insulin in refrigerator.   Complete a rapid glucose test.  Draw red-top tube of blood.  Give 1 to 2 liters of saline.  If blood glucose levels are not available give fluid and 25G D50.  The additional sugar will not hurt them but if they are in hypoglycemia it may save them.  If the patient is a know alcoholic consider giving 100mg prior to sugar.

HYPERGLYCEMIC HYPEROSMOLAR NONKETOTIC COMA (HHNK)

Serious complication associated with diabetes.  Both insulin and glucagons activity are present.  This condition occurs when: 1) Sustained hyperglycemia causes osmotic diuresis to produce dehydration.  2) Water intake is inadequate to replace fluids.  Most common causes are; , , and certain drugs.  This patient still has insulin working so the are not present.  40 to 70 mortality.  How to pick it out = slower onset than , over days.  Increase urination and thirst.  Volume depletion.  Dry skin, Confused.  Treatment is same as because it is hard to diagnose in field.

Hypoglycemia is a medical emergency.  It takes hours for the brain to switch from sugar metabolism to fat metabolism and the damage cannot be reversed while waiting.  Signs include stumbles, rage, and bizarre behavior.  If levels fall critically low are common.  Always consider when faced with a patient with bizarre behavior.  The onset is .  Care is if glucose is less than 60 mg/dl draw red top.  25 to 50G D50,   If IV cannot be started give 0.5 to 1 mg IM. 

                                                   

HYPERTHYROIDISM is thyroid hormones in blood. 

THYROTOXICOSIS is exposure to  excessive thyroid hormones.

HYPOTHYROIDISM is thyroid levels.

MYXEDEMA is long term exposure to levels of thyroid hormones.

                                                  

GRAVES’ DISEASE

Graves’ Disease accounts for over of and 15% have relatives with the disease.  Graves’ is more common in .  Onset is 20’s to 30’s.  Autoimmune autobodies keep stimulating the thyroid to produce too much.  Signs are agitation, insomnia, tachycardia, increase appetite, poor heat tolerance.  Protrusion of the and large goiter.  Care is monitor cardiac activity.  Beta blockers may help heart. Steroid like may quickly reduce T4 levels.

THYROTOXIC CRISIS also know as

True life-threatening and kills within hours.  Most common when body is under stress from trauma or infection.  The patient has inactive thyroid circulating but for some reason the inactive becomes active which overdoses the blood.  Signs are increased activity of sympathetic system, high 106, delirium, coma, tachycardia, vomit, diarrhea.  Same as Graves is the care.

                                         

Hypothyroidism

Creates a metabolic state.  This results in poor handling of exercise and infection.  Over time develops into is a thickening of connective tissue in skin and other tissue organs of the body like the heart.  Become hypothermic in nature, and go into a stuporous state called .  Sings include slowing mental status and function, decrease appetite with weight gain, constipation, bradycardias.  Care is support ABC and cardiac.  Limit fluids to not alter electrolyte balance.

                                            

Adrenal Gland

is called .  Cushings syndrome is relatively common.  Middle aged persons with women more than men.  Excess which is a , can be caused by the or adrenal cortex.  Also people who are treated with steroid such as . Early sign is . Long term exposure to steroids is an antagonist to insulin so can develop.  Fat metabolism is altered so is common.  Sodium retention so they look puffy.  Earliest sign is WEIGHT GAIN in the trunk and face and neck.  A develops.  A develops.  Thinning of skin and women getting facial hair.  Care is limited in field remember that atherosclerosis and hypertension can lead to heart problems and strokes.  Use care when starting an IV.

is caused from .  It is due to steroid destruction.  This is an disease like .  Infection and trauma can be a problem because the do not have proper steroid production.  Addison’s causes major disturbances in water and electrolyte balance.  Increase excretion cause low volume but an increase in to hyperkalemia is likely. One cause of Addison’s is use of steroids like prednisone.  While on the drug the adrenal glands are suppressed.  Signs include fatigue, weight loss, hyperpigmentation of skin.  Care is aggressive fluid if needed, check sugar levels and treat, get 12 lead and ECG monitory  for cardiac events.

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